Characterization of a Common Susceptibility Locus for Asthma-Related Traits
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چکیده
منابع مشابه
Characterization of a Common Susceptibility Locus for Asthma-related Traits
sure to air pollution adversely affects the growth of lung function during rapid lung development and if it has clinically significant adverse effects on final lung function attained during adolescence. Study Population. Fourth-grade children (average age: 10 years) were enrolled and followed prospectively for 8 years. Methods. Fourth-grade children (n 1759) were recruited from elementary schoo...
متن کاملCharacterization of a Common Susceptibility Locus for Asthma-related Traits
sure to air pollution adversely affects the growth of lung function during rapid lung development and if it has clinically significant adverse effects on final lung function attained during adolescence. Study Population. Fourth-grade children (average age: 10 years) were enrolled and followed prospectively for 8 years. Methods. Fourth-grade children (n 1759) were recruited from elementary schoo...
متن کاملCharacterization of a common susceptibility locus for asthma-related traits.
Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein-coupled receptor named GPRA (G protein-coupled receptor for asthma susceptibilit...
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Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discus...
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Almost all major causes of ill-health and premature death in human societies worldwide - including cancer, cardiovascular disease, diabetes and many infectious diseases - are, at least in part, genetically determined. Typically, risk of succumbing to one of these illnesses is thought to depend on both the individual repertoire of variation within a number of key susceptibility genes and the his...
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ژورنال
عنوان ژورنال: Pediatrics
سال: 2005
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.2005-0698ss